We are particularly interested in developing new computational methods to use genomic DNA methylation and chromatin modification data to understand the functional relationship between these marks and gene expression.  We have a particular interest in applying new methods in machine learning and data mining to unravel potential functional consequences of epigenetic changes in human disease, including cancer.

 

WIMSi - Washington University Interpolated Methylation Signatures

A new method to find patterns of DNA methylation that associate with expression changes in genomic datasets.  A variation of this approach can be used to elucidate a list of genes likely regulated by DNA methylation.